Cancer Cells Self-Destruct When "SWEET
TOOTH" Is Thwarted
Johns Hopkins Press Release February
.Johns Hopkins researchers have found
evidence that some cancer cells are such incredible sugar junkies that
they'll self-destruct when deprived of glucose, their biological sweet
..."The change when we took away
glucose was dramatic," says Chi Van Dang, M.D., Ph.D., director of
hematology. "By the next day, we knew very quickly that the cells we
had altered to resemble cancers were dying off in large numbers."
..Scientists have long suspected that
the cancer cell's heavy reliance on glucose, its main source of
strength and vitality, also could be one of its great weaknesses, and
Dang's new results are among the most direct proofs yet of the idea.
Results of the study, published in the
February 17 issue of the Proceedings of the National Academy of
Sciences, suggest that drugs which cut off the glucose supply may be a
potent way of fighting cancer with few ill effects on healthy tissues.